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Category: Aging
Emerging Interface Between Metabolic Syndrome And Asthma.
Authors: Agrawal A, Mabalirajan U, Ahmad T, Ghosh B There is growing epidemiological evidence that obesity increases the risk of developing asthma. In some studies, insulin resistance or metabolic syndrome is a stronger risk factor than body mass. The obese-asthma subphenotype is marked by a paucity of inflammation but marked symptoms, poor response to glucocorticoids, and peripheral airway dy
Category: Asthma
TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma.
Conclusions: TSLP variants are significantly associated with bronchial asthma and pulmonary function. Thus, TSLP might be a therapeutic target molecule for combination therapy. PMID: 20656951 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free
Category: Asthma
Thromboxane Synthase Inhibitors and Thromboxane A(2) Receptor Antagonists: A Quantitative Structure Activity Relationships (QSARs) Analysis.
Authors: Kontogiorgis C, Hadjipavlou-Litina D Thromboxane A(2) (TxA(2)), a bioactive metabolite of the Arachidonic acid (AA), is a potent mediator of platelet aggregation, vasoconstriction and bronchoconstriction. It plays an important role in major human diseases, such as myocardial infraction, unstable angina, pregnancy-induced hypertension and preeclampsia, thrombosis and thrombotic disorde
Category: Asthma
Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells
Type A human seasonal influenza (FluA) virus infection causes exacerbations of bronchial asthma and chronic obstructive pulmonary disease (COPD). l-carbocisteine, a mucolytic agent, reduces the frequency of common colds and exacerbations in COPD. However, the inhibitory effects of l-carbocisteine on FluA virus infection are uncertain. We studied the effects of l-carbocisteine on FluA virus infect
Category: Asthma
AP-1 overexpression impairs corticosteroid inhibition of collagen production by fibroblasts isolated from asthmatic subjects
This study determined the effect of dexamethasone (Dex) on collagen production by bronchial fibroblasts derived from asthmatic and healthy subjects. Expression of procollagen mRNA in fibroblasts from asthmatics and normal controls was determined by quantitative PCR. Regulation of the procollagen-1I promoter was evaluated by transient transfections. Transforming growth factor-β (TGF-β) p
Category: Asthma
Acute cigarette smoke inhalation blunts lung responsiveness to methacholine and allergen in rabbit: differentiation of central and peripheral effects
Despite the prevalence of active smoking in asthmatics, data on the short-term effect of acute mainstream tobacco smoke exposure on airway responsiveness are very scarce. The aim of this study was to assess the immediate effect of acute exposure to mainstream cigarette smoke on airway reactivity to subsequent nonspecific and allergenic challenges in healthy control (n = 5) and ovalbumin-sensitize
Category: Asthma
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