Abstract The World Trade Center disaster and its recovery work involved a range of hazardous occupational exposures that have not been
fully characterized but that can be reasonably assumed to have the potential to cause mucosal inflammation, preferentially
(but not exclusively) in the upper airway. A high prevalence of rhinosinusitis and upper airway disease (UAD) symptoms was
reported by several early surveys. Clinical studies demonstrated objective, clinically significant, and persistent chronic
perennial rhinosinusitis and UAD—with or without seasonal exacerbation—in a large proportion of patients. Demonstration of
an association between UAD and available exposure indicators has been limited. Atopy seemed to be associated with increased
UAD symptom severity and to ...
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