Abstract Mast cells are present in nearly all vascularized tissues, but not the blood. They are best known for the prominent role they
play in atopic disease. However, our current understanding of their direct and indirect roles in the immune response offers
a more nuanced picture of both villain and hero. Although they are implicated in many inflammatory disorders, they also defend
us from bacterial pathogens, prevent dangerous overreactions by the immune system, and even protect us from snake venom. Perhaps
there is more to these maligned cells than we thought.
Content Type Journal ArticleDOI 10.1007/s11882-009-0052-zAuthors
John J. Ryan, Virginia Commonwealth University Department of Biology P. O. Box 842012 1000 West Cary Street Richmond VA 23284-2012 USAJosephine F...
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