Conclusions Because of their undemonstrated effectiveness, SGAs should be avoided in patients with dementia complicated by psychotic and/or behavioural symptoms. Hence, further researches are urgently needed to identify useful pharmacological strategies that can be used to improve the clinical condition of such patients and to reduce burden to caregivers when behavioural interventions
Health Topics » Alzheimer
Chemistry and Pharmacology of GABA(B) Receptor Ligands.
Authors: Froestl W This chapter presents new clinical applications of the prototypic GABA(B) receptor agonist baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine, morphine, and heroin, a novel baclofen prodrug Arbaclofen placarbil, the GABA(B) receptor agonist AZD3355 (Lesogabaran) currently in Phase 2 clinical trials for the treatment of gastroesophag
Category: Alzheimer
Rapidly Progressive Dementia: Causes Found in a Greek Tertiary Referral Center, in Athens
We examined the relative frequency of the underlying causes of RPD, in a university tertiary referral center, in Athens. A series of consecutive patients presenting with RPD in a 3-year period was included. All patients received a comprehensive clinical, imaging, and laboratory evaluation. Of a total of 279 patients hospitalized for dementia diagnosis, 68 patients had RPD (37 males and 31 females
Category: Alzheimer
Grid computing tackles Alzheimerâs disease
Source: eHealthNews.eu Content: “Technological advances have taken the medical world to a whole new level, as digital infrastructure and state-of-the-art software offer doctors and patients the right tools for diagnosis and treatment. Helping to advance the technology further is the NEUGRID (A grid-based e-infrastructure for data archiving/communication and computationally intensive applica
Category: Alzheimer
Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing
Recent studies suggest that dementia in the most elderly (90 years of age and above) is only modestly related to Alzheimer’s disease pathology. This raises the possibility that other, as yet unknown, disease processes may underlie dementia in this rapidly growing demographic group, and that efforts designed to combat Alzheimer’s disease may not be appropriate for treating dementia in
Category: Alzheimer
Midlife psychological stress and risk of dementia: a 35-year longitudinal population study
The number of people with dementia has increased dramatically with global ageing. Nevertheless, the pathogeneses of these diseases are not sufficiently understood. The present study aims to analyse the relationship between psychological stress in midlife and the development of dementia in late-life. A representative sample of females (n = 1462) aged 38–60 years were examined in 1968–6
Category: Alzheimer
S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons
A major phenotype seen in neurodegenerative disorders is the selective loss of neurons due to apoptotic death and evidence suggests that inappropriate re-activation of cell cycle proteins in post-mitotic neurons may be responsible. To investigate whether reactivation of the G1 cell cycle proteins and S phase entry was linked with apoptosis, we examined homocysteine-induced neuronal cell death in
Category: Alzheimer
Upper and Lower Extremity Motor Performance and Functional Impairment in Alzheimer's Disease
This report examines the relation of upper and lower extremity motor performance to functional impairment among 371 persons with probable Alzheimer’s disease (AD). Cognitive and motor performance tests were administered at 6-month intervals for up to 4 years. Motor performance was assessed using 3 lower extremity tests and 2 upper extremity tests. Functional impairment was measured at 3-mon
Category: Alzheimer
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