Dementia is a very common problem, and Alzheimer disease (AD) is the most common cause of dementia. More than 24 million people in the world have dementia, and the number is rising as the population ages. AD is a terrible disease that causes impaired cognition and function in the patient and much suffering on the part of the caregivers. It is the fifth leading cause of death in the United States.
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In December, The U.S. Food and Drug Administration (FDA) approved the first generic versions of Aricept (donepezil hydrochloride) orally disintegrating tablets. Donepezil hydrochloride is indicated for the treatment of dementia related to Alzheimer disease (AD). “Generics offer greater access to health care for all Americans,” said Gary Buehler, director of the FDA's Office of Generic Drugs. “Hea
Category: Alzheimer
Prion Disease in Mice May Help Advance Alzheimer's Research
Title: Prion Disease in Mice May Help Advance Alzheimer's ResearchCategory: Health NewsCreated: 3/5/2010 2:10:00 PMLast Editorial Review: 3/8/2010 (Source: MedicineNet Alzheimer)
Category: Alzheimer
An Alzheimer disease presenilin mutation, syndrome diversity, and a shrinking world
(Source: Neurology)
Category: Alzheimer
Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation
Conclusions: Genealogic and molecular findings provided evidence that the PSEN1 Met146Leu families from around the world analyzed in this study are related and represent a single kindred originating from Southern Italy. The marked phenotypic variability might reflect early involvement by the pathologic process of different cortical areas. Although the clinical phenotype is quite variable, the neu
Category: Alzheimer
Untreated Poor Vision: A Contributing Factor to Late-Life Dementia
Ophthalmologic abnormalities have been described in patients with dementia, but the extent to which poor vision and treatment for visual disorders affect cognitive decline is not well defined. Linked data from the Health and Retirement Study and Medicare files (1992–2005) were used to follow the experiences of 625 elderly US study participants with normal cognition at baseline. The outcome
Category: Alzheimer
The role of macrophage migration inhibitory factor in Alzheimer's disease.
Authors: Bacher M, Deuster O, Aljabari B, Egensperger R, Neff F, Jessen F, Popp J, Noelker C, Reese JP, Al-Abed Y, Dodel R Previous studies have shown that amyloid beta protein (Abeta ), the essential molecule for the formation of toxic oligomers and, subsequently, Alzheimer plaques, has been associated in vivo with the immune modulator, macrophage migration inhibitory factor (MIF) (17). To fu
Category: Alzheimer
Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology
Abstract In Alzheimer’s disease (AD), Purkinje neurons in the cerebellum are spared, while, for instance, pyramidal neurons in the hippocampus are neuropathologically affected. Several lines of evidence suggest that the pathogenesis could be induced by the concentration-dependent polymerization of the amyloid β-peptide (Aβ) into extracellular oligomers. The role of intracellular Aβ is
Category: Alzheimer
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