Structural markers based on MRI are radically changing how Alzheimer's disease is conceptualized, from its preclinical to overt stages. Nature Reviews Neurology (Source: Medscape Today Headlines)
Health Topics » Alzheimer
Driving With Early Alzheimer's May Be Ill-Advised
Title: Driving With Early Alzheimer's May Be Ill-AdvisedCategory: Health NewsCreated: 3/11/2010 4:10:00 PMLast Editorial Review: 3/12/2010 (Source: MedicineNet Alzheimer)
Category: Alzheimer
The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating {gamma}-Secretase Complex Assembly and Dictating the Amyloid {beta} Peptide (A{beta}) Profile without Affecting Notch Processing [Enzymology]
In this study we have examined the role of the large hydrophilic loop (amino acids 320–374, encoded by exon 10) of presenilin 1 (PS1), the catalytic subunit of -secretase, for -secretase complex formation and activity on Notch and APP processing. Deletion of exon 10 resulted in impaired PS1 endoproteolysis, -secretase complex formation, and had a differential effect on Aβ-peptide produ
Category: Alzheimer
Loss of Function of ATXN1 Increases Amyloid {beta}-Protein Levels by Potentiating {beta}-Secretase Processing of {beta}-Amyloid Precursor Protein [Molecular Bases Of Disease]
In this study, we ask whether ATXN1 may lead to AD pathogenesis by affecting Aβ and APP processing utilizing RNA interference in a human neuronal cell model and mouse primary cortical neurons. We show that knock-down of ATXN1 significantly increases the levels of both Aβ40 and Aβ42. This effect could be rescued with concurrent overexpression of ATXN1. Moreover, overexpression of AT
Category: Alzheimer
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-{beta} Peptide Metabolism [Neurobiology]
Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-β (Aβ) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK). Resveratrol also lowers Aβ levels in cell lines; however, the underlying me
Category: Alzheimer
Early Onset Alzheimer's Disease - Facts and Information
Alzheimer's disease usually starts with symptoms that are subtle and therefore poorly recognized, such as memory failure. (Source: Disabled World)
Category: Alzheimer
'Current Alzheimer reseach' helps accelerate the progress of the field.
Authors: Kahiri DK PMID: 20214570 [PubMed - in process] (Source: Current Alzheimer Research)
Category: Alzheimer
Alzheimer's 'Epidemic' Hitting Minorities Hardest
Title: Alzheimer's 'Epidemic' Hitting Minorities HardestCategory: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/10/2010 (Source: MedicineNet Alzheimer)
Category: Alzheimer
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