Soluble oligomers of Aβ42 peptide are believed to play a major role in the pathogenesis of Alzheimer disease (AD). It was recently found that at least some of the neurotoxic effects of these oligomers may be mediated by specific binding to the prion protein, PrPC, on the cell surface (Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., and Strittmatter, S. M. (2009) Nature 457,
Health Topics » Alzheimer
Polymorphic Assembly and Stability of Human Tau Fibrils [Protein Structure and Folding]
Fibrous aggregates of Tau protein are characteristic features of Alzheimer disease. We applied high resolution atomic force and EM microscopy to study fibrils assembled from different human Tau isoforms and domains. All fibrils reveal structural polymorphism; the "thin twisted" and "thin smooth" fibrils resemble flat ribbons (cross-section ~10 x 15 nm) with diverse twist periodicities. "Thick fib
Category: Alzheimer
Calpain and BACE1 Expression [Neurobiology]
Abnormal activation of calpain is implicated in synaptic dysfunction and participates in neuronal death in Alzheimer disease (AD) and other neurological disorders. Pharmacological inhibition of calpain has been shown to improve memory and synaptic transmission in the mouse model of AD. However, the role and mechanism of calpain in AD progression remain elusive. Here we demonstrate a role of calpa
Category: Alzheimer
Requiring an amyloid-β1-42 biomarker for prodromal Alzheimer's disease or mild cognitive impairment does not lead to more efficient clinical trials
Abstract: Background: Low cerebrospinal fluid (CSF) amyloid-β1-42 concentration and high total-tau/Aβ1-42 ratio have been recommended to support the diagnosis of prodromal Alzheimer's disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and also to select patients for clinical trials (Shaw et al, Ann Neurol 2009;65:403â13; Dubois et al, Lancet Neurol 2007;6:734â46).Method
Category: Alzheimer
Alzheimer's Association Update September 2010
Nearly 4,000 researchers from 60 countries gathered in Honolulu, Hawaii, July 10â15 to learn the latest in Alzheimer research at the Alzheimer's Association International Conference on Alzheimer's Disease (AAICAD) 2010. The world's largest gathering of Alzheimer's disease (AD) researchers included a full day of presentations focused on imaging technologies related to early detection and diagnos
Category: Alzheimer
Puzzling claims over brain games
ConclusionThis study has some strengths, including the large number of patients followed and the long follow-up period. Furthermore, its clinical evaluations and assessments of cognitive function were based on validated measures. The participants also represent a broad spectrum of cognitive function, ranging from no impairment to dementia.However, the study also has limitations. It did not make
Category: Alzheimer
Mental 'Exercise' May Only Hide Signs of Alzheimer's
Title: Mental 'Exercise' May Only Hide Signs of Alzheimer'sCategory: Health NewsCreated: 9/1/2010 6:10:00 PMLast Editorial Review: 9/2/2010 (Source: MedicineNet Alzheimer)
Category: Alzheimer
Health Tip: Signs That People With Dementia Shouldn't Drive
Title: Health Tip: Signs That People With Dementia Shouldn't DriveCategory: Health NewsCreated: 8/31/2010 10:10:00 AMLast Editorial Review: 9/1/2010 (Source: MedicineNet Alzheimer)MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network, and receive $5 free advertising.
Category: Alzheimer
LiftSP Anti-Wrinkle Cream
Sort News
Lose Weight with Acai
