Register | Login

Health Topics » Alzheimer

The Clinical Use of Structural MRI in Alzheimer Disease

Structural markers based on MRI are radically changing how Alzheimer's disease is conceptualized, from its preclinical to overt stages. Nature Reviews Neurology (Source: Medscape Today Headlines)



Category: Alzheimer

Driving With Early Alzheimer's May Be Ill-Advised

Title: Driving With Early Alzheimer's May Be Ill-AdvisedCategory: Health NewsCreated: 3/11/2010 4:10:00 PMLast Editorial Review: 3/12/2010 (Source: MedicineNet Alzheimer)



Category: Alzheimer

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating {gamma}-Secretase Complex Assembly and Dictating the Amyloid {beta} Peptide (A{beta}) Profile without Affecting Notch Processing [Enzymology]

In this study we have examined the role of the large hydrophilic loop (amino acids 320–374, encoded by exon 10) of presenilin 1 (PS1), the catalytic subunit of -secretase, for -secretase complex formation and activity on Notch and APP processing. Deletion of exon 10 resulted in impaired PS1 endoproteolysis, -secretase complex formation, and had a differential effect on Aβ-peptide produ



Category: Alzheimer

Loss of Function of ATXN1 Increases Amyloid {beta}-Protein Levels by Potentiating {beta}-Secretase Processing of {beta}-Amyloid Precursor Protein [Molecular Bases Of Disease]

In this study, we ask whether ATXN1 may lead to AD pathogenesis by affecting Aβ and APP processing utilizing RNA interference in a human neuronal cell model and mouse primary cortical neurons. We show that knock-down of ATXN1 significantly increases the levels of both Aβ40 and Aβ42. This effect could be rescued with concurrent overexpression of ATXN1. Moreover, overexpression of AT



Category: Alzheimer

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-{beta} Peptide Metabolism [Neurobiology]

Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-β (Aβ) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK). Resveratrol also lowers Aβ levels in cell lines; however, the underlying me



Category: Alzheimer

Early Onset Alzheimer's Disease - Facts and Information

Alzheimer's disease usually starts with symptoms that are subtle and therefore poorly recognized, such as memory failure. (Source: Disabled World)



Category: Alzheimer

'Current Alzheimer reseach' helps accelerate the progress of the field.

Authors: Kahiri DK PMID: 20214570 [PubMed - in process] (Source: Current Alzheimer Research)



Category: Alzheimer

Alzheimer's 'Epidemic' Hitting Minorities Hardest

Title: Alzheimer's 'Epidemic' Hitting Minorities HardestCategory: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/10/2010 (Source: MedicineNet Alzheimer)



Category: Alzheimer
LiftSP Anti-Wrinkle Cream

Now with Acai: Click here to get a free trial!
Sort News
Username:

Password:

Remember:
Lose Weight with Acai