Conclusions: PSNHDD appears to be a clinically informative end point measure, especially when used with a grace period, and is as sensitive as most traditional outcome measures in detecting differences between the medication and placebo groups. Nonetheless, these findings should be replicated in other clinical data sets, particularly with medications that work via different mechanisms. PMID: 2
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Liver Disease and HPLC Quantification of Disialotransferrin for Heavy Alcohol Use: A Case Series.
Conclusions: Liver abnormalities, but not necessarily cirrhosis, are common in individuals with poor chromatographic separation of transferrin glycoforms, which might lead to false-positive results on CDT testing. However, the chromatographic-based assay can detect this issue, minimizing the reporting of false positives, but not necessarily assisting in valid detection of heavy drinking. PMID:
Category: Alcoholism
Familial Loading for Alcoholism and Offspring Behavior: Mediating and Moderating Influences.
Conclusions: Findings support previously proposed but untested pathways in etiologic models of alcoholism and show the potentially important role of active parenting in reducing the expression of inherited vulnerability to alcoholism in childhood. PMID: 20659068 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Category: Alcoholism
Individual Differences in Problem Drinking Among Tribal Members From One First Nation Community.
Conclusions: The findings support the theory that personality traits and psychosocial learning are important determinants of problem drinking in First Nation people and Caucasians. PMID: 20659067 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Category: Alcoholism
Screening, Brief Intervention, and Referral to Treatment (SBIRT): 12-Month Outcomes of a Randomized Controlled Clinical Trial in a Polish Emergency Department.
Conclusions: Data suggest that improvements in drinking outcomes found in the assessment condition were not because of assessment reactivity, with both the screened and intervention conditions demonstrating greater (although nonsignificant) improvement than the assessed condition. Only those in the intervention condition showed significant improvement in all outcome variables from baseline to 12-
Category: Alcoholism
The Preventive Effect of Oral EGCG in a Fetal Alcohol Spectrum Disorder Mouse Model.
Conclusions: In a murine model, oxidative stress appears to play an important role in ethanol-induced embryonic growth retardation. EGCG can prevent some of the embryonic injuries caused by ethanol. PMID: 20659071 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Category: Alcoholism
Alcohol-Induced Exacerbation of Ischemic Brain Injury: Role of NAD(P)H Oxidase.
Conclusions: Our findings suggest that NAD(P)H oxidase may play an important role in exacerbated ischemic brain injury during chronic alcohol consumption. PMID: 20659070 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Category: Alcoholism
Reduced Resource Optimization in Male Alcoholics: N400 in a Lexical Decision Paradigm.
Conclusions: These results suggest a reduced flexibility in the cognitive networks and a lack of resource optimization in alcoholics. The reduced attenuation of N400 during the primed condition in the alcohol dependent subjects may reflect an inability to engage similar neuronal substrates associated with semantic relatedness as seen in the controls. As diminished N400 attenuation during priming
Category: Alcoholism
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